Stability of dicyclohexylamine and fumagillin in honey
2015
van den Heever, Johan P. | Thompson, Thomas S. | Curtis, Jonathan M. | Pernal, Stephen F.
Fumagillin is extensively used to control nosema disease in apiculture. In the commercial formulation, fumagillin is present as a salt in an equimolar quantity with dicyclohexylamine (DCH). In this study DCH was observed to be significantly more resistant to degradation in honey than fumagillin using LC–MS/MS analysis. Observed half-lives for DCH ranged from a minimum of 368days when kept at 34°C in darkness, to a maximum of 852days when stored at 21°C in darkness. A maximum half-life of 246days was observed for fumagillin in samples kept in darkness at a temperature of 21°C. The observed half-life of fumagillin was estimated to be 3days when exposed to light at 21°C, and complete decomposition was observed after 30days under the same conditions. The stability of DCH, combined with its genotoxicity and tumorigenic properties make it an important potential contaminant in honey destined for human consumption.
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