Atractylmacrols A-E, sesquiterpenes from the rhizomes of Atractylodes macrocephala
2018
Wang, Shuang-Yan | Ding, Lin-Fen | Su, Jia | Peng, Li-Yan | Song, Liu-Dong | Wu, Xing-De
Phytochemical investigation of the rhizomes of Atractylodes macrocephala led to the isolation of five new sesquiterpenes, atractylmacrols A-E (1-5), as well as six known eudesmane sesquiterpenes (6-11). The structures of 1-5 were determined through interpretation of their 1D and 2D NMR spectroscopic data, as well as HREIMS values. Compounds 1-5 were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW264.7 macrophages.
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