Convenient synthesis of enantiopure (R-) and (S-)-3-fluoro-3-aminomethylpyrrolidines
2014
Yarmolchuk, Vladimir S. | Mykhalchuk, Vladimir L. | Mykhailiuk, Pavel K.
(R-)- and (S-)-3-fluoro-3-aminomethylpyrrolidines were synthesized from methyl α-fluoroacrylate in eight steps. α-Phenylethylamine was used as a chiral auxiliary to separate the racemic mixture. The overall synthesis yield was 31%.
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Bibliographic information
Publisher
Elsevier Ltd
Other Subjects
Drug design; [3+2]; Diamines; Pyrrolidine; Enantiomers; Cycloaddition
Language
English
Type
Journal Article; Text
2024-02-27
MODS
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