C–C Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature

Lipshutz, Bruce H.; Huang, Shenlin; Leong, Wendy Wen Yi; Isley, Nicholas A.

C–C Bond Formation via Copper-Catalyzed Conjugate Addition Reactions to Enones in Water at Room Temperature

2012

Lipshutz, Bruce H. | Huang, Shenlin | Leong, Wendy Wen Yi | Isley, Nicholas A.

Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I), Ag(I), and Au(III) leads to 1,4-adducts in good isolated yields: no organometallic precursor need be formed.

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AGROVOC Keywords

copper gold mixing silver zinc

Bibliographic information

Published in

Journal of the American Chemical Society

Volume 134 Issue 49 Pagination 19985 - 19988 ISSN 1520-5126

Publisher

American Chemical Society

Other Subjects

Chemical bonding; Ambient temperature

Language

English

License

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Type

Text; Journal Article

In AGRIS since: 2024-02-27

Format: MODS

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Links

DOI http://dx.doi.org/10.1021%2Fja309409e

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