Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors
2016
Diedrich, D. | Hamacher, A. | Gertzen, C. G. W. | Alves Avelar, L. A. | Reiss, G. J. | Kurz, T. | Gohlke, H. | Kassack, M. U. | Hansen, F. K.
A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as potent HDAC6 inhibitors with a selectivity over other HDAC isoforms. The most potent HDAC6 inhibitor revealed remarkable chemosensitizing properties and completely reverted the cisplatin resistance in Cal27 CisR cells.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library