Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae)
2021
Abdelkarem, Fahd M. | Desoky, Ezz-Eldin K. | Nafady, Alaa M. | Allam, Ahmed E. | Mahdy, Aldoushy | Ashour, Ahmed | Mohamed, Gamal A. | Miyamoto, Tomofumi | Shimizu, Kuniyoshi
Two new polyhydroxylated steroids, 3β-acetoxy-gorgost-5α,6β,11α-triol (3) and (23 R) methylergosta-20-ene-3β,5α,6β,17α-tetrol (4), together with three known gorgosteroid compounds, gorgost-3β, 5α,6β,11α- tetrol (1), 11α-acetoxy-gorgost- 3β,5α, 6β- triol (2), and gorgost-5 (E) ene-3-β-ol (5), as well as batyl alcohol (6), were isolated from the Egyptian soft coral Heteroxenia fuscescens. The structures of these compounds were elucidated based on NMR spectroscopic analyses, HR-FAB-MS, and comparisons with published data. The cytotoxic activities of the fractions and compounds were evaluated against MCF-7 cancer cell lines using MTT colorimetric assay. Compounds 2 and 4 showed moderate cytotoxic activity, with IC₅₀ values equal to 33.2 and 25.1 µM, respectively, in comparison with the IC₅₀ of 5-fluorouracil 18.7 µM.
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