Ruthenium Catalyzed Intramolecular C–S Coupling Reactions: Synthetic Scope and Mechanistic Insight
2016
Sharma, Shivani | Pathare, Ramdas S. | Maurya, Antim K. | Gopal, Kandasamy | Roy, Tapta Kanchan | Sawant, Devesh M. | Pardasani, Ram T.
A ruthenium catalyzed intramolecular C–S coupling reaction of N-arylthioureas for the synthesis of 2-aminobenzothiazoles has been developed. Kinetic, isotope labeling, and computational studies reveal the involvement of an electrophilic ruthenation pathway instead of a direct C–H activation. Stereoelectronic effect of meta-substituents on the N-arylthiourea dictates the final regioselective outcome of the reaction.
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