A facile synthesis of 4-azaisoindoles and their transformation into novel pyrrole-fused 2-pyridones
2021
Kiren, Sezgin | Grimes, Felicia | Mohammed, Hassan | Alazawi, Doaa
We describe herein a novel, efficient and practical synthetic approach to access pyrrolo[3,4-b]pyridines from dihydropyridones in three steps, in which a pyrrole unit is generated from a dihydropyridone using TosMIC reagent. Protection of the resulting pyrrole, Grignard addition followed by oxidative aromatization afford substituted pyrrolo[3,4-b]pyridines. These underutilized structures are subsequently transformed to novel pyrrole-fused 2-pyridones via N-alkylation and then oxidation.
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