Studies towards the stereoselective total synthesis of Gliomasolide A

Kare, Nagaraju; Kundoor, Govinda Reddy; Palakodety, Radha Krishna

Studies towards the stereoselective total synthesis of Gliomasolide A

2019

Kare, Nagaraju | Kundoor, Govinda Reddy | Palakodety, Radha Krishna

The first synthetic approach towards the Gliomasolide A is described in 15 linear steps with 4% overall yield. The key steps in this approach are RCM protocol for the construction of 14-member macrolide, a Sharpless kinetic resolution, Keck and Brown’s allylations for the installation of desired stereocenters.

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AGROVOC Keywords

chemical structure

Bibliographic information

Published in

Tetrahedron letters

ISSN 0040-4039

Publisher

Taylor & Francis

Other Subjects

Cross-metathesis; Macrolides; Stereoselectivity; Allylation; Ring-closing metathesis; Asymmetric keck and brown’s allylations; Sharpless kinetic resolution

Language

English

Note

Pre-press version

Type

Text; Journal Article

In AGRIS since: 2024-02-27

Format: MODS

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