Inhibition of dopamine-beta-hydroxylase by cytokinins
1992
Abdelnour-Esquivel, A. | Kaminek, M. | Armstrong, D.J.
The activity of cell-free preparations of dopamine-beta-hydroxylase from a mammalian source was inhibited by a number of N6-substituted adenine derivatives that are hormonally active as cytokinins in plant systems. The synthetic cytokinin N6-cyclohexylmethyladenine exhibited inhibitory activity equivalent to that of 1-phenyl-3-(2-thiazolyl)-2-thiourea (PTTU), a compound known to be a potent inhibitor of dopamine-beta-hydroxylase activity. PTTU itself was found to exhibit cytokinin activity in the tobacco callus bioassay and to inhibit the activity of the plant enzyme, cytokinin oxidase. The possible significance of these observations is discussed in relation to known effects of cytokinins on phenethylamine metabolism.
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