MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2
2015
Zhang, Zhiqi | Hou, Changhe | Meng, Fangang | Zhao, Xiaoyi | Zhang, Ziji | Huang, Guangxin | Chen, Weishen | Fu, Ming | Liao, Weiming
The expression of miR-455-3p has been shown to be up-regulated in chondrogenesis of mesenchymal stem cell, but its role in different stages during chondrogenesis remains unknown. Here, we show that miR-455-3p is increased in ATDC5 cells from 0d to 21d, but rapidly decreases at 28d, and a similar expression kinetic is detected in the development of mouse embryos. We show that miR-455-3p functions as an activator for early chondrogenic differentiation, most likely by inhibiting the expression of Runt-related transcription factor 2 (Runx2) as indicated by luciferase reporter assays. In conclusion, miR-455-3p may activate early chondrogenesis by directly targeting Runx2.
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