Diversity-Oriented Synthesis of Fluoromethylated Arenes via Palladium-Catalyzed C–H Fluoromethylation of Aryl Iodides
2022
Du, Yiming | Chen, Shuxin | Huang, Ao | Chen, Yihan | Liu, Yun-Lin | Song, Gaopeng | Tang, Ri-Yuan | Xu, Hanhong | Yao, Guangkai | Li, Zhaodong
Herein we report the first versatile and expeditious method for the site-selective C–H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the diversity-oriented synthesis (DOS) of fluoromethylated arenes. This methodology features the use of the low-cost industrial raw material CH₂IF as the fluoromethyl source, an excellent functional group tolerance, and a broad ipso termination scope and can be expanded to the late-stage modification of biorelevant molecules.
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