Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
2012
Hayakawa, Ichiro | Ikedo, Akiyuki | Chinen, Takumi | Usui, Takeo | Kigoshi, Hideo
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O⁷-modified glaziovianin A showed strong cytotoxicity against HeLa S₃ cells. Compared to glaziovianin A, the O⁷-benzyl and O⁷-propargyl analogues were more cytotoxic against HeLa S₃ cells and more potent M-phase inhibitors. Furthermore, O⁷-modified molecular probes of glaziovianin A were synthesized for biological studies.
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