A pyrophosphate-activated nanochannel inspired by a TRP ion channel
2019
Beilingguidao, | Yang, Guanxing | Dhinakaran, Manivannan Kalavathi | Wang, Rui | Song, Miaomiao | Li, Haibing
A pyrophosphate (PPi) selectively activated potassium channel was constructed via introducing the isoniazid functionalized calix[4]arene (C4NP) into a biomimetic nanochannel. The activation mechanism is mainly due to the changing of the inner surface charge and wettability of the nanochannel caused by PPi binding.
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