Bioactive secondary metabolites from roots of Cissus rheifolia planch
2021
Promgool, Trinop | Kanokmedhakul, Kwanjai | Tantapakul, Cholpisut | Suchaichit, Natcha P. | Yahuafai, Jantana | Siripong, Pongpun | Kelemen, Cristina D. | Kokoska, Ladislav | Kanokmedhakul, Somdej
Two new aromadendrin rhamnosides, cissusfoliate A (1) and 3-epi-cissusfoliate A (2) together with seven known compounds (3-9) were isolated from the roots of Cissus rheifolia Planch. Their structures were determined by extensive spectroscopic methods. The absolute configurations of compounds 1-5 were assigned by combination of the J coupling constant values of H-2 and H-3 and the comparison of their experimental ECD spectra with those reported in literature. Compounds 1, 3 and 5-8 showed antioxidant effects on ORAC, ATBS and DPPH assays as well as antibacterial activity against six pathogenic bacterial strains. Their cytotoxicity against Hela, KB, MCF-7, HepG2 and HT-29 cell lines were also evaluated.
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