Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer
2014
Kim, Minkyu | Gkikas, Manos | Huang, Aaron | Kang, Jeon Woong | Suthiwangcharoen, Nisaraporn | Nagarajan, R. (Ramanathan) | Olsen, Bradley D.
A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.
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