Streamlined process for the esterification and ketalization of shikimic acid en route to the key precursor for oseltamivir phosphate (Tamiflu™)
2008
Carr, Robert | Ciccone, Frank | Gabel, Richard | Guinn, Martin | Johnston, David | Mastriona, Jill | Vandermeer, Trevor | Groaning, Michael
In an effort to streamline the current process for the key precursor en route to Tamiflu™ (oseltamivir phosphate), the ketalization reaction was re-evaluated for areas of improvement. Removal of thionyl chloride was a priority from a EH & S and operational perspective. Finally, the reduction of solvents and telescoping steps would improve throughput and minimize waste streams.
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