Libraries from libraries: a series of sulfonamide linked heterocycles derived from the same scaffold
2013
Debevec, Ginamarie | Chen, Wenteng | Yu, Yongping | Houghten, Richard A. | Giulianotti, Marc A.
A libraries from libraries approach is described for the synthesis of five different sulfonamide linked scaffolds. Four of the scaffolds are sulfonamides linked to heterocycles; piperazine, thiourea, cyclic guanidine, and dimethyl cyclic guanidine. The fifth scaffold is a polyamine linked sulfonamide. Three different diversity positions were effectively incorporated into each scaffold providing a number of different compounds with good yields and purity.
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