Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol–ene/thiol–yne photoreactions
2010
Aimetti, Alex A. | Feaver, Kristen R. | Anseth, Kristi S.
A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol–ene click reaction and subsequent clustering using thiol–yne photochemistry. Both reactions utilize the sulfhydryl group on natural cysteine amino acids to participate in the thiol-mediated reactions.
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