<b>The influence of estradiol and progesterone and melatonin supplementation on TNF-</b><b>a</b><b> levels in ovariectomized and pinealectomized rats</b>
2006
Oztekin, Esma | Mogulkoc, R. | Baltaci, A. K. | Tiftik, A. M.
The aim of this study was to investigate the effect of estradiol and progesterone and melatonin supplementation on TNF-a levels in ovariectomized and pinealectomized rats. The study was carried out on 42 adult, Spraque-Dawley strain female rats aged 6 months and weighing 200-250 grams. The rats were divided into 6 groups, each group contained 7 rats. Group 1: Sham-ovariectomized (Sham-Ovx), Group 2: Ovariectomized (Ovx), Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) group, Group 4: Ovx+E-P+Melatonin (M) supplemented group, Group 5: Ovx - Pinealectomized (Pnx) group, Group 6: Ovx - Pnx+E-P supplemented group. Serum TNF-a levels were determined after 4 weeks application period. Group 6 (Ovx-Pnx+E-P) has the highest serum TNF-a compared with other groups while group 2 (ovariectomized), has the lowest levels (P<0.001). Group 5 was higher than groups 1, 2, 3 and 4 (P<0.001). The results of the study show that ovariectomy reduces the serum level of TNF-a, but estradiol and progesterone application prevents this reduction in ovariectomized rats. However, pinealectomy intensifies the increases in TNF- a levels in ovariectomized and estradiol and progesterone supplemented rats, whereas melatonin reduces TNF- a levels in ovariectomized rats.
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