Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development

DIETRICH, JES; Doherty, T. Mark

Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development

2009

DIETRICH, JES | Doherty, T. Mark

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major worldwide health problem that causes more than 2 million deaths annually. In addition, an estimated 2 billion people are latently infected with M. tuberculosis. The bacterium is one of the oldest human pathogens and has evolved complex strategies for survival. Therefore, to be successful in the high endemic regions, any future TB vaccine strategy will have to be tailored in accordance with the resulting complexity of the TB infection and anti-mycobacterial immune response. In this review, we will discuss what is presently known about the interaction of M. tuberculosis with the immune system, and how this knowledge is used in new and more advanced vaccine strategies.

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AGROVOC Keywords

apoptosis clinical trials drug therapy epidemiology humans immunology interleukins macrophages microbiology mycobacterium tuberculosis pattern recognition phagocytosis physiology receptors tuberculosis tuberculosis vaccination vaccines vaccines

Bibliographic information

Published in

APMIS

Volume 117 Issue 5 Pagination 440-457 - 457 ISSN 0903-4641

Publisher

Elsevier Ltd

Other Subjects

Subunit; Tuberculosis vaccines; Therapeutic use; Prevention & control; Host-pathogen interactions; Antitubercular agents; Latency; Bacterial; Macrophage activation; Bcg; Global health; Interferon-gamma; Synthetic; Phase ii as topic; Drug design; Bcg vaccine; Adult

Language

English

Type

Text; Journal Article

In AGRIS since: 2024-02-28

Format: MODS

Data Provider

This bibliographic record has been provided by National Agricultural Library

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Links

DOI http://dx.doi.org/10.1111/j.1600-0463.2009.02458.x

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