Aminoaciduria in chronic renal failure--its relationship to vitamin D and parathyroid status
1980
Phillips, Malcolm E. | Havard, Jayne | Otterud, Brith
Aminoaciduria is common and often severe in chronic renal failure patients, based on measurements of fractional clearances of amino acids. Additional measurements of vitamin D metabolites and serum parathyroid hormone (PTH) were made in patients with this condition, plus secondary hyperparathyroidism and osteomalacia. Treatment with vitamin D metabolites, particularly 1,25(OH)2D3, improved amino acid transport and amino acid reabsorption. The effect on transport was independent of PTH serum levels. Deficiency of 1,25(OH)2D3 may be a key factor in defective amino acid reabsorption in chronic renal failure patients, and in the tubular dysfunction found in such conditions as the Fanconi syndrome, rickets, and osteomalacia. The findings lend little support to the view that excess PTH causes aminoaciduria.
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