Effective chemoselective deprotection of 3,4-dimethoxybenzyl (³,⁴DMB) ethers in the presence of benzyl and p-methoxybenzyl (PMB) ethers by phenyliodine(III) bis(trifluoroacetate) (PIFA)
2011
Watanabe, Kazuhiro | Katoh, Tadashi
In this Letter, a selective deprotection of the alcohol protecting 3,4-dimethoxybenzyl (³,⁴DMB) group is described. The hypervalent iodine(III) reagent phenyliodine bis(trifluoroacetate) (PIFA) is found to be an efficient reagent for the chemoselective deprotection of ³,⁴DMB ethers in the presence of benzyl, p-methoxybenzyl, methoxymethyl, tert-butyldimethylsilyl, and tert-butyldiphenylsilyl ethers under mild conditions. This is the first example of the selective deprotection of the ³,⁴DMB group from a hydroxy group with PIFA.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library