Defective photoproduction of cholecalciferol in normal and uremic humans
1984
Jacob, Allan I. | Sallman, Alan | Santiz, Zenaida | Hollis, Bruce W.
Blood levels of vitamin D (as ergocalciferol and cholecalciferol (D3), 25-hydroxyvitamin D and, 1,25-dihydroxyvitamin D were measured in 17 black and 9 white uremic hemodialysis patients and in 9 black and 14 white normal subjects to assess the effects of chronic uremia on the photoproduction and circulatory levels of vitamin D. Blood vitamin D levels were similar in uremic and normal white subjects, and were greater than in normal black subjects (as was 25-hydroxyvitamin D). Further, vitamin D was not detected in 12 of the 17 normal black subjects. Exposure to a single dose of ultraviolet-B radiation depressed the maximal increase in blood plasma vitamin D in white uremic patients, relative to normal subjects. The results suggest that chronic uremic hemodialysis patients have a reduced capability for photoproduction of cholecalciferol, despite having normal epidermal levels of its precursor, 7-hydrocholesterol. (wz)
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