Death in the fast lane: what's next for necroptosis?
2016
Oberst, Andrew
Necroptosis is a form of programmed cell death that is both mechanistically and morphologically distinct from apoptosis, the canonical mechanism of cell suicide. Although early descriptions of necroptosis date back decades, the last 5 years have seen a proliferation of studies of this process. This surge in interest has included the recent publication of several excellent, in‐depth reviews of the literature [Chan FK‐M et al. (2014) Annu Rev Immunol 33, 141210135520002; Weinlich R & Green DR (2014) Mol Cell 56, 469–480; Silke J et al. (2015) Nat Immunol 16, 689–697; Linkermann A & Green DR (2014) N Engl J Med 370, 455–465]. Rather than contribute another summary to this well‐summarized field, in this Minireview I will briefly discuss key recent findings, then touch on some of the major outstanding questions – the known unknowns – that remain.
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