Effect of sucrose polyester on fecal steroid excretion by 24 normal men
1980
Sucrose polyester (SPE) has physical properties like conventional dietary fats, but physiologically it differs in being neither digested nor absorbed. Over three consecutive 10-day periods, 24 healthy men received varying amounts of SPE supplements to various basal diets. The amount of C27 steroids (cholesterol and its conversion products formed by intestinal bacteria) were measured in each subject's feces. Compared to the basal period, each gram of ingested SPE resulted in a 1.3% increased excretion, 6.3 mg, of these steroids. In subjects receiving a diet with less than 50 mg cholesterol per day, SPE probably caused the increase by interfering with the absorption of endogenous enterohepatic circulating cholesterol. The relationships between SPE intake levels and varying degrees of cholesterol in the basal diets are explored.
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