USP7: combining tools towards selectivity
2019
Gjonaj, Lorina | Sapmaz, Aysegul | González-Prieto, Román | Vertegaal, Alfred C. O. | Flierman, Dennis | Ovaa, Huib
Active-site directed probes based on the ubiquitin scaffold have been successfully applied as tools to determine the levels of active deubiquitinating enzymes (DUBs). Here, we show the development of a Ub-based reagent selective for the DUB USP7. This concept can be applied for the generation of other new selective reagents.
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