In vitro and in vivo gene delivery using polyethylenimine-poly(hydroxyethyl glutamine) as a non-viral carrier
2011
Polyethylenimine-poly(hydroxyethyl glutamine) copolymer (PEI-PHEG) could effectively form positively charged nanoparticles with pDNA. The PEI-PHEG copolymer exhibited much lower cytotoxicity and higher gene transfection efficiency than PEI-25k with different cell lines in vitro. PEI-PHEG/pDNA complex demonstrated excellent transfection efficiency in animal tests. PEI-PHEG could efficiently deliver siRNA to cells to silence the target gene. It could also complex vascular endothelial growth factor siRNA (VEGF siRNA) to achieve the aim of tumor therapy.
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