Feeding of scallop mantle epithelial cell layer causes subacute toxicity against rodents
2018
Hasegawa, Yasushi | Itagaki, Daisuke | Konno, Kiwako | Hasegawa, Chihiro
Japanese scallops Patinopecten yessoensis are one of the main marine products of Hokkaido, Japan. In addition to adductor muscle, scallop mantle tissue is also eaten in Japan. We fed Wistar rats diets containing the scallop mantle epithelial cell layer for 3–8 weeks and compared the outcomes with a control group. No differences in general appearance or behavior were observed between the groups for the first 2 weeks. Thereafter, a significant decrease in food consumption was observed, and the treated rats died between 6 and 8 weeks. Serum biochemistry and histological studies revealed nephrotoxicity and hepatotoxicity in rats fed scallop mantle epithelial cells. Glucose tolerance tests showed that feeding scallop mantle epithelial cells to rats causes a glucose metabolism disorder. A diet containing a water extract from scallop mantle epithelial cells caused toxicity in mice, but a diet containing a methanol extract, which dissolves diarrhetic shellfish poisoning (DSP) toxin, or an extract in heated 0.1 M HCl, which dissolves paralytic shellfish poisoning (PSP) toxin, did not cause toxicity. Mice fed a diet containing pronase-treated water extract neither showed a decrease in their food intake nor death. These results suggest that a water-soluble component other than DSP or PSP toxin causes toxicity.
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