Cas9 in Human Embryos: On Target but No Repair
2020
Hoffmann, Eva R. | Roig, Ignasi
In this issue of Cell, Zuccaro and colleagues show that on-target Cas9-mediated double-strand breaks cause chromosome loss or mis-repair of the disease allele in > 90% of human embryos. End joining repair pathways dominate, causing small insertions or deletions, which raises serious questions about using double-strand breaks for “gene surgery”.
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