A DNA-templated synthesis of encoded small molecules by DNA self-assembly
2014
Cao, Cheng | Zhao, Peng | Li, Ze | Chen, Zitian | Huang, Yanyi | Bai, Yu | Li, Xiaoyu
We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chemical reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution.
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