Optochemical control of gene expression by photocaged guanine and riboswitches
2018
Dhamodharan, V. | Nomura, Yoko | Dwidar, Mohammed | Yokobayashi, Yohei
Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.
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