Oral Administration of Freeze-Dried Kefir Reduces Intestinal Permeation of and Oral Sensitization to Ovalbumin in Mice
2005
UMEDA, Chisato | SONOYAMA, Kei | YAMAGUCHI, Natsu | SAITO, Ryo | AKASHI, Keiko | MOTOSHIMA, Hidemasa | KAWABATA, Jun
An increase in plasma ovalbumin concentrations after intragastric administration of ovalbumin was suppressed by concomitant freeze-dried kefir in BALB/c mice. Serum levels of ovalbumin-specific immunoglobulin G and proliferation of splenic mononuclear cells in mice immunized orally with ovalbumin were suppressed by feeding freeze-dried kefir. We propose that kefir reduces intestinal permeation of food antigen, which contributes to suppression of oral sensitization.
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