Synthesis of oxazino[4,3-a]indoles by domino addition-cyclization reactions of (1H-indol-2-yl)methanols and vinyl selenones in the presence of 18-crown-6
2016
Palomba, Martina | Vinti, Elisa | Marini, F. (Francesca) | Santi, Claudio | Bagnoli, Luana
Herein we report the synthesis of biologically relevant oxazino[4,3-a]indoles by an environmentally friendly Michael addition-cyclization cascade using potassium hydroxide in dichloromethane employing variously substituted vinyl selenones and (1H-indol-2yl)methanols.The addition of 18-crown-6, as a complexing agent, is crucial to achieve high chemo- and regio-selectivity.
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