Kadcotriones A–C: Tricyclic Triterpenoids from Kadsura coccinea
2013
Liang, Cheng-Qin | Shi, Yi-Ming | Li, Xing-Yao | Luo, Rong-Hua | Li, Yan | Zheng, Yong-Tang | Zhang, Hong-Bin | Xiao, Wei-Lie | Sun, Han-Dong
Three new triterpenoids, kadcotriones A–C (1–3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14β-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods. Compounds 2 and 4 exhibited anti-HIV-1 activities with EC₅₀ values of 30.29 and 54.81 μM, respectively.
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