Total Synthesis of Ritterazine B
2021
Nakayama, Yasuaki | Maser, Michael R. | Okita, Tatsuya | Dubrovskiy, Anton V. | Campbell, Taryn L. | Reisman, Sarah E.
The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. The synthesis features a unified approach to both steroid subunits, employing a titanium-mediated propargylation reaction to achieve divergence from a common precursor. Other key steps include gold-catalyzed cycloisomerizations that install both spiroketals and late stage C–H oxidation to incorporate the C7′ alcohol.
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