Visible-light promoted one-pot synthesis of pyrazoles from alkynes and hydrazines
2019
Meng, Yunge | Zhang, Te | Gong, Xinchi | Zhang, Min | Zhu, Chunyin
A visible-light promoted cascade of Glaser coupling/annulation has been developed for one-pot synthesis of polysubstituted pyrazoles from alkynes and hydrazines. The method features mild reaction conditions, readily availible starting materials and green oxidant (O2). It works for a wide range of substituted phenyl acetylene and hyrazines with good functional group tolerance and efficiency. Mechanistic pathways including photochemical irridiation, intramolecular hydrogen-atom-abstraction (HAT) and enamine-to-imine tautomerization was proposed for the transformation.
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