A practical synthesis of C14–C26 fragment of anticancer drug, eribulin mesylate
2015
Lavanya, Nadella | Kiranmai, Nayani | Mainkar, Prathama S. | Chandrasekhar, Srivari
High yielding synthesis of C14–C26 fragment of eribulin is achieved from commercially available R-(+)-citronellol and 1,4-butane diol utilizing the chirality of citronellol ‘methyl’ centre as C25, organocatalytic epoxidation to install C23 chirality and Sharpless asymmetric dihydroxylation to install chirality at C20 and C17.
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