Simultaneous quantitation of quetiapine and its active metabolite norquetiapine in rat plasma and brain tissue by high performance liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS)
2015
Yang, Xiangkun | Poddar, Indrani | Hernandez, Caterina M. | Terry, Alvin V. | Bartlett, Michael G.
A sensitive method to simultaneously quantitate quetiapine and norquetiapine in rat plasma and brain tissue was developed using a one-step liquid–liquid extraction for sample preparation and LC-MS/MS for detection. The method provided a linear range of 1.0–500.0ng/mL for each analyte in plasma and 3.0–1500.0ng/g in brain tissue. The method was validated with precision within 15% relative standard deviation (RSD), accuracy within 15% relative error (RE), matrix effects within 10% and a consistent recovery. This method has been successfully applied in a preclinical study of quetiapine and norquetiapine to simultaneously determine their concentrations in rat plasma and brain tissue.
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