Thiophene and bioisostere derivatives as new MMP12 inhibitors
2011
Badland, Matthew | Compère, Delphine | Courté, Karine | Dublanchet, Anne-Claude | Blais, Stéphane | Manage, Ajith | Peron, Guillaume | Wrigglesworth, Roger
A new MMP12 inhibitor series has been identified containing a thiophene moiety. Different approaches have been considered to replace this potential toxicophore. α-Fluorothiophene derivatives were the most interesting compounds. Their synthesis is presented.
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