DABCO-catalyzed ring opening of activated cyclopropanes and recyclization leading to γ-lactams with an all-carbon quaternary center
2014
Lin, Shaoxia | Li, Ling | Liang, Fushun | Liu, Qun
A novel and efficient method for the construction of γ-lactams with an all-carbon quaternary center is developed via a DABCO-catalyzed reaction of EWG-activated cyclopropanecarboxamides and electron-deficient alkenes. The process involves sequential ring-opening of activated cyclopropanes, intermolecular Michael addition and intramolecular aza-cyclization.
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