Silyl-protected propargyl glycine for multiple labeling of peptides by chemoselective silyl-deprotection
2021
Kamo, Naoki | Hayashi, Gosuke | Okamoto, Akimitsu
We synthesized Fmoc-propargyl glycine derivatives bearing different silyl protecting groups that can be readily introduced by using a standard solid-phase peptide coupling procedures. Taking advantage of the orthogonality between the different silyl protecting groups, chemoselective incorporation of functional molecules into a 19-mer peptide through click reactions was demonstrated.
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