Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines
2017
Woods, Brian P. | Orlandi, Manuel | Huang, Chung-Yang | Sigman, Matthew S. | Doyle, Abigail G.
A Ni-catalyzed reductive cross-coupling of styrenyl aziridines with aryl iodides is reported. This reaction proceeds by a stereoconvergent mechanism and is thus amenable to asymmetric catalysis using a chiral bioxazoline ligand for Ni. The process allows facile access to highly enantioenriched 2-arylphenethylamines from racemic aziridines. Multivariate analysis revealed that ligand polarizability, among other features, influences the observed enantioselectivity, shedding light on the success of this emerging ligand class for enantioselective Ni catalysis.
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