Multicarbazole scaffolds for selective G-quadruplex binding
2018
Ou, Arnold | Guédin, Aurore | Skelton, Brian W. | Amrane, Samir | Evans, Cameron W. | Norret, Marck | Iyer, K Swaminathan | Mergny, Jean-Louis | Smith, Nicole M.
Herein we report a new class of G-quadruplex stabilising ligands, multicarbazoles, which display high G-quadruplex DNA selectivity in the presence of 250 times excess duplex DNA. We report the synthesis of these compounds in moderate to high yields. Ligands in the series with optimal G-quadruplex selectivity contain an N-propylamino chain length where the amino functionalities are either pyrrolidine or piperidine.
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