A new polyethyleneinmine-gold nanoparticles-protoporphyrin cobalt (II) nanocomposite for electrochemical hydrogen peroxide biosensing
2019
Liu, Yanju | Yan, Shuxun | Li, Manman | Wang, Ke | Zeng, Dai | Yang, Huaixia
In this assay, a new polyethyleneinmine-gold nanoparticles-protoporphyrin cobalt (II) (PEI-AuNPs-CoPP) nanocomposite was synthesized by a simple method under mild conditions, and it was used to fabricate an electrochemical sensor for the detection of hydrogen peroxide (H₂O₂). The structures of nanomaterials were characterized by fourier transform infrared (FTIR) spectroscopy and ultraviolet visible spectrometry (UV–vis). Under the optimum condition, the current intensity was linearly related to H₂O₂ concentration in the range of 50–280 aM (R² = 0.9932). It's worth mentioning that a lower detection limit of 7.26 aM was obtained at a signal-to-noise rate of 3. In addition, the experiments showed that ascorbic acid (AA), uric acid (UA) and glucose (Glu) had little effect on the determination of H₂O₂. The sensor had a good analytical performance for the determination of H₂O₂ in human serum samples. These results suggested that the proposed PEI-AuNPs-CoPP nanocomposites had practical application prospect in biological sample analysis and clinical diagnosis.
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