Gene Golden Age paradox and its partial solution
2019
Vinogradov, A.E. | Anatskaya, O.V.
The prevalence of purifying selection in the nature suggests that larger organisms bear a higher number of slightly deleterious mutations because of smaller populations and therefore weaker selection. In this work redistribution of purifying selection in favor of information genes, pathways and processes was found in primates compared with treeshrew and rodents on the ground of genome-wide analysis. The genes which are more favored in primates belong mainly to regulation of gene expression and development, in treeshrew and rodents, to metabolism, transport, energetics, reproduction and olfaction. The former occur predominantly in the nucleus, the latter, in the cytoplasm and membranes. Thus, although purifying selection is on average weaker in the primates, it is stronger concentrated on the “information technology” of life (regulation of gene expression and development). Increased accuracy of information processes probably allows escaping “error catastrophes” in spite of more complex organization, larger body size and higher longevity.
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