Robust electrochemical system for screening single nucleotide polymorphisms
2011
Hu, Rong | Wu, Zai-Sheng | Zhang, Songbai | Shen, Guo-Li | Yu, Ruqin
A highly sensitive and selective electrochemical DNA signaling scheme, which identifies the point mutation existing in target DNA sequence, is developed based on the combination of label-free hairpin probe (HP)/DNA endonuclease with zirconia (ZrO₂) nanoparticle film, representing a promising screening platform for the accurate diagnosis of infections and genetic diseases as well as for environmental and forensic applications.
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