Synthesis of rodocaine
2011
Zhang, Mengyang | Tai, Hang-Yi | Chen, Yeh-Long
A new method for synthesis of rodocaine (1) is presented. Two key steps were carried out by the N-bromosuccinimide (NBS)-mediated intermolecular addition of known enamine 5 with allyltrimethyl silane in presence of boron trifluoride etherate (BF₃/OEt₂) and the intramolecular ring-closing metathesis of triene 3. The Diels–Alder cycloaddition of triene 3 with different ethyl propiolates was also studied.
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