Crystal Structure of Na⁺, K⁺-ATPase in the Na⁺-Bound State
2013
Nyblom, Maria | Poulsen, Hanne | Gourdon, Pontus | Reinhard, Linda | Andersson, Magnus | Lindahl, Erik | Fedosova, Natalya | Nissen, Poul
Pumping Out Sodium Mammalian cells contain relatively high concentrations of potassium but low concentrations of sodium. This balance is maintained by an ion pump, the Na ⁺, K ⁺–adenosine triphosphatase, in an adenosine triphosphate–driven transport cycle that results in the export of three sodium ions and the import of two potassium ions. Structures of potassium-bound conformations of the pump have been determined. Now, Nyblom et al. (p. 123, published online 19 September) report on the high-resolution crystal structure of a Na ⁺-bound conformation, which reveals conformational changes associated with Na ⁺ binding.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library