Self-assembling nanowires of an amphiphilic camptothecin prodrug derived from homologous derivative conjugation
2016
HeThese authors contributed equally to this work., Dongxuan | Zhang, Wei | Deng, Hongzhang | Huo, Shuaidong | Wang, Yi-Feng | Gong, Ningqiang | Deng, Liandong | Liang, Xing-Jie | Dong, Anjie
A novel amphiphilic camptothecin prodrug, CPT-ss-Ir, consisting of CPT, Ir and a disulfide bond linker, was synthesized, and it could self-assemble into nanowires in aqueous solution. Upon intracellular triggering, active CPT and Ir species were released to exert a considerable anticancer effect.
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